HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 916825Generated: November 2, 2026
Methanesulfonyl chloride → 2-(4-{[tert-Butyl(dimethyl)silyl]oxy}phenyl)ethyl methanesulfonate
https://huagongshe.com/reaction/916825
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2-(4-((Tert-butyldimethylsilyl)oxy)phenyl)ethan-1-ol | HCID 11288221 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(4-{[tert-Butyl(dimethyl)silyl]oxy}phenyl)ethyl methanesulfonate | HCID 59768101 | — |
Reaction Steps
A solution of 2-(4-((tert-butyl(dimethyl)silyl]oxy}phenyl)ethanol (653 mg) and diisopropylethylamine (1.8 ml) in DCM (15 ml) at 0° under nitrogen was treated with methanesulfonyl chloride (0.44 ml) and the mixture was stirred at 0° C. for 6 h. Saturated NaHCO3 solution was added and the mixture stirred for 15 min. Water (20 ml) was added and the mixture was extracted with DCM. The extract was dried (Na2SO4) and the solvent evaporated in vacuo to give the title compound (904 mg). LCMS RT=3.85 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07271197B2 |
|---|
| Source dataset | uspto-grants-2007_09 |
|---|
| ORD ID | ord-3360c2922bbf45d4bb8785bd341ef57c |
|---|
| Source note | uspto-grants-2007_09 |
|---|
