Isopropylamine → HCID 69386027, compound

Participants

Reaction Steps

A solution of 3-{[2-(4-{2-[(5R)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-oxo-1,3-oxazolidin-3-yl]ethyl}phenoxy)ethoxy]methyl}benzoic acid (90 mg) and isopropyl amine (9.7 mg) in DMF (2 ml) was cooled to 0° C. and treated with diisopropylethylamine (0.057 ml) and O-benzotriazol-1-yl-N,N,N′,N′-tetramethyluronium hexafluorophosphate (HBTU) (62 mg). This was then stirred for 8 h before diluting in EtOAc and washing sequentially with 2M HCl, NaHCO3 (aq) and brine. The combined organic layers were then dried (MgSO4) and concentrated in vacuo to give the title compound(112 mg). LCMS RT=3.36 min.

Provenance & Evidence