Sodium Carbonate → HCID 69392516, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (5R)-5-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-3-[2-(4-{2-[(3-iodobenzyl)oxy]ethoxy}phenyl)ethyl]-1,3-oxazolidin-2-one {Example 6 i)} (150 mg), 3-(methoxycarbonyl)phenylboronic acid (47 mg), tetrakis(triphenylphosphine)palladium (0) (6 mg) and 2N sodium carbonate (7 mL) in dimethoxyethane (10 mL) was heated at 85° C. for 1 h. The solution was then diluted in EtOAc, washed with water, dried (MgSO4) and concentrated in vacuo. The residue was purified by chromatography (Biotage, 40 g) eluting with CH2Cl2-MeOH (200:1) to give the title compound (128 mg). LCMS RT=3.99 min.

Provenance & Evidence