Methanesulfonyl chloride → HCID 86601666, compound

Participants

Reaction Steps

To a solution of 3-({2-[4-(2-hydroxyethyl)phenoxy]ethoxy}methyl)benzonitrile (5.04 g) and diisopropylethylamine (5.94 ml) in dichloromethane (50 ml) at 0° C. was added methanesulphonyl chloride (1.58 ml) dropwise and the mixture allowed to stir for 2 h. The resultant mixture was partitioned between dichloromethane and saturated sodium hydrogen carbonate. The organic phase was dried (MgSO4) and concentrated in vacuo to give the title compound (6.02 g). LCMS RT=3.22 min.

Provenance & Evidence