Tetrahydrofuran → HCID 69385147, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 3-({2-[4-(2-{[(2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]amino}ethyl)phenoxy]ethoxy}methyl)benzonitrile (4.6 g) in tetrahydrofuran (70 ml) was treated with potassium trimethylsilanoate (9.32 g) and heated at 70° C. for 71 h. The reaction mixture was concentrated in vacuo and partitioned between ethyl acetate and water. The aqueous phase was extracted with ethyl acetate and the combined organic phase washed with brine, dried (MgSO4) and concentrated in vacuo. The residue was purified by chromatography (SPE, eluted with a gradient between dichloromethane and 10% methanol in dichloromethane) to give the title compound (1.01 g). LCMS RT=2.42 min.

Provenance & Evidence