Hydrochloric Acid → HCID 69423902, compound

Participants

Reaction Steps

To a solution of 3-[(2-{4-[2-({(2R)-2-hydroxy-2-[4-hydroxy-3-(hydroxymethyl)phenyl]ethyl}amino)ethyl]phenoxy}ethoxy)methyl]benzamide (25 mg) in iso-propanol (0.45 ml) was added hydrochloric acid (12M, 5.1 μl). A heat-cool cycle was applied between 0° C. and 40° C., and the mixture agitated for 90 h. The precipitate was filtered to give the title compound (20 mg). Mp 151- 153° C.; 1H NMR δ (CD3OD, 400 MHz) 7.88 (1H, br s), 7.78 (1H, br d, J 8 Hz), 7.55 (1H, d, J 8 Hz), 7.43 (1H, t, J 8 Hz), 7.34 (1H, br d, J 2 Hz), 7.22-7.13 (3H, m), 6.92 (2H, br d, J 8 Hz), 6.77 (1H, d, J 8 Hz), 4.65 (4H, d, J 7 Hz), 4.16-4.11 (2H, br t, J 4 Hz), 3.87-3.81 (2H, br t, J 4 Hz), 3.27-3.20 (2H, br t, J 8 Hz), 2.98-2.90 (2H, m).

Provenance & Evidence