Cesium carbonate → HCID 23034279, compound

Participants

Reaction Conditions

Reaction Steps

Under a nitrogen atmosphere, methyl N-(t-butyloxycarbonyl)-3-amino-3-(4-toluenesulfonyloxyphenyl)propionate (0.45 g, 1.0 mmol), cesium carbonate (0.65 g, 2.0 mmol), tricyclohexylphosphine (0.059 g, 0.2 mmol), bis(1,5-cyclooctadiene)nickel (0.028 g, 0.1 mmol) and 2,6-dimethoxyphenylboronic acid (0.36 g, 2.0 mmol) were mixed in dioxane (1 ml). The reaction mixture was heated to 50° C. and then stirred at the same temperature for 2 hrs. After the reaction was completed, the mixture was left to cool to room temperature and insoluble substances were filtered off. The filtrate was subjected to column chromatography purification to obtain methyl N-(t-butyloxycarbonyl)-3-amino-3-[4-(2,6-dimethoxyphenyl)phenyl]propionate (0.34 g, yield 83%) as colorless oil.

Provenance & Evidence