Hydrochloric Acid → HCID 69417551, compound

Participants

Reaction Steps

To a solution of methyl 2-(methoxy)-6-(4-chlorophenyl)-5-(phenyl)pyridine-3-carboxylate (150 mg, 0.42 mmol) from Example 5 in methanol (5 mL) was added 5N sodium hydroxide (0.42 mL, 2.1 mmol). The reaction was stirred at rt for 72 h and was then diluted with water and acidified with 2N hydrochloric acid. The mixture was extracted twice with methylene chloride. The organic layers were washed with a portion of brine and the combined organic layers were dried over anhydrous sodium sulfate and concentrated in vacuo to give the crude title product as a white solid.

Provenance & Evidence