1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)- → HCID 58961600, compound

Participants

Role	Name	HCID	Charge
Reactant	1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-	HCID 11325	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	6-(2,4-Dichlorophenyl)-5-(4-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile	HCID 21984825	—
Solvent	Dimethylformamide	HCID 6228	—
Product	HCID 58961600	HCID 58961600	—

Reaction Conditions

Temperature	70 °C

Reaction Steps

To the product of Step B Example 19 (600 mg, 1.597 mmol) was added N-(2-bromoethyl)-phthalimide (690 mg, 2.715 mmol), K2CO3 (331 mg, 2.396 mmol) and DMF (8 mL). The mixture was heated to 70° C. for 20 hours. The mixture was filtered, concentrated and passed through a short plug of silica gel eluting with 33% ethyl acetate/hexane. The partially purified material was carried on without further purification. MS (electrospray) m/e 547.8 MH+ (retention time=4.4 min LC/MS).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07271266B2
Source dataset	uspto-grants-2007_09
ORD ID	ord-42fb3a302b5b49a29257d121b5d51ab2
Source note	uspto-grants-2007_09