Acetonitrile → HCID 58961604, compound

Participants

Reaction Conditions

Reaction Steps

To the product of Example 25 (971 mg) was added acetonitrile (14 mL) and ethanol (5 mL). The mixture was heated to 80° C. to dissolve the material before adding hydrazine hydrate (0.60 mL, 12.24 mmol). After 2.3 hours the mixture was filtered through Celite®545 diatomaceous earth and then concentrated. The residue was purified by flash chromatography (silica gel) eluting with 2% triethylamine/4% methanol/94% dichloromethane affording the product. MS (electrospray) m/e 418.0 MH+ (retention time=3.0 min LC/MS).

Provenance & Evidence