Benzoyl chloride → HCID 58961581, compound

HRID 916936Notes

Reaction equation

HRID 916936 reaction equation
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:10][CH2:11][CH2:12][O:13][C:14]1[N:21]=[C:20]([C:22]2[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][C:23]=2[Cl:29])[C:19]([C:30]2[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][CH:31]=2)=[CH:18][C:15]=1[C:16]#[N:17]>>[Cl:36][C:33]1[CH:32]=[CH:31][C:30]([C:19]2[CH:18]=[C:15]([C:16]#[N:17])[C:14]([O:13][CH2:12][CH2:11][NH:10][C:1](=[O:8])[C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[N:21][C:20]=2[C:22]2[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][C:23]=2[Cl:29])=[CH:35][CH:34]=1

Participants

3

Reactant 2

HCID 7412Benzoyl chlorideHCID 58961604HCID 58961604, compound

Product 1

HCID 58961581HCID 58961581, compound

Procedure

In the following Examples 28-31, the procedure described in Example 27 was repeated but substituting the appropriate acid chloride for benzoyl chloride in the reaction with 2-(2-aminoethoxy)-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)-nicotinonitrile from Example 26 to afford the following compounds:

Workup

  1. customto afford the following compounds

Sources & evidence

ORD record
ord-8970f3a22a364630ae203250e622b134
Source dataset
uspto-grants-2007_09
Patent number
US07271266B2

Reaction notes

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