1-Aminopiperidine → HCID 44390753, compound

Participants

Reaction Steps

To a portion of the methylene chloride (1 mL) solution of 2-(chloro)-6-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyridine-3-carbonyl chloride (0.068 mmol) from Step B was added a solution of 1-aminopiperidine (0.010 mL, 0.088 mmol) and TEA (0.014 mL, 0.10 mmol) in methylene chloride (1 mL). The reaction was stirred at rt for 16 h and was then evaporated. The residue was purified by preparative TLC (40% ethyl acetate in hexanes) to yield N-(piperidin-1-yl)-2-(chloro)-6-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyridine-3-carboxamide. HPLC/MS: 494 (M+1), 496 (M+3); Rt=3.97 min

Provenance & Evidence