Hydrochloric Acid → HCID 69415176, compound

Participants

Reaction Steps

To a solution of methyl 2-(benzyloxy)-6-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyridine-3-carboxylate (390 mg, 0.78 mmol) from Example 51, Step B in methanol (5 mL) was added 5N sodium hydroxide (0.31 mL, 1.56 mmol). The reaction was stirred at rt 20 h and then at 40° C. for 1 h. The reaction was diluted with water, acidified with 2N hydrochloric acid, and extracted twice with methylene chloride. The organic layers were washed with a portion of brine and the combined organic layers were dried over anhydrous sodium sulfate and concentrated in vacuo to give crude 2-(benzyloxy)-6-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyridine-3-carboxylic acid.

Provenance & Evidence