Hydrochloric Acid → HCID 69415319, compound

Participants

Reaction Steps

To a solution of methyl 6-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyridine-3-carboxylate (170 mg, 0.43 mmol) from Example 61, Step B in methanol (5 mL) was added 5N sodium hydroxide (0.20 mL, 1.0 mmol). The reaction was stirred at rt for 20 h and was then acidified with 2N hydrochloric acid and extracted twice with methylene chloride. The organic layer was washed with a portion of brine, dried over sodium sulfate, and concentrated in vacuo to give 6-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyridine-3-carboxylic acid as a white solid. HPLC/MS: 378 (M+1), 380 (M+3); Rt=3.65 min

Provenance & Evidence