Methylamine hydrochloride → HCID 10174842, compound

Participants

Reaction Steps

To a portion of the methylene chloride (1 mL) solution of 2-(3,4-difluorobenzyloxy)-6-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyridine-3-carbonyl chloride (0.044 mmol) was added methylamine hydrochloride (6 mg, 0.088 mmol) and TEA (0.018 mL, 0.13 mmol). The reaction was stirred at rt for 16 h and was then evaporated. The residue was purified by preparative TLC eluted with 25% ethyl acetate in hexanes to yield N-(methyl)-2-(3,4-difluorobenzyloxy)-6-(2,4-dichlorophenyl)-5-(4-chlorophenyl)pyridine-3carboxamide. HPLC/MS: 533 (M+1), 535 (M+3); Rt=4.77 min

Provenance & Evidence