Sodium Hydroxide → HCID 58961586, compound

Participants

Reaction Conditions

Reaction Steps

A solution of the product from Example 104 Step F (0.280 g; 0.541 mmol) in methanol (4 mL) and THF (1 mL) in a round bottom flask was treated with 3N aq. NaOH (1.08 mL; 3.24 mmol) and heated to 50° C. for 2 hours. The volatiles were removed in vacuo, and the reaction was quenched with saturated aq. NaHSO4 solution and extracted with methylene chloride (5×). The combined extracts were dried (Na2SO4), filtered, and concentrated in vacuo to afford the crude product. NMR and LCMS indicated good purity and the crude product was used without further purification: m/e=504 (M+1).

Provenance & Evidence