Cesium carbonate → HCID 58961606, compound

Participants

Reaction Conditions

Reaction Steps

To an oven-dried round bottom flask was added toluene (1 mL), the product of Example 112 (0.050 g; 0.122 mmol), and 3,4-difluorophenol (0.016 g; 0.122 mmol), and cesium carbonate (0.044 g; 0.134 mmol). The reaction mixture was heated at 100° C. and stirred for 4 hours. The reaction mixture was allowed to cool to room temperature, then it was partitioned between ethyl acetate and 2N aq. NaOH solution. The organic portion was separated and washed with more 2N aq. NaOH solution (2×), brine, dried (Na2SO4), filtered, and concentrated in vacuo. Purification was done by MPLC (silica gel; 0-10% ethyl acetate:hexane) to afford the desired product: m/e=504 (M+1) Rt=4.61 min on LCMS.

Provenance & Evidence