1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)- → HCID 58961583, compound

HRID 916983Notes

Reaction equation

HRID 916983 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[NH:13][C:12](=[O:14])[C:11]([C:15]#[N:16])=[CH:10][C:9]=1[C:17]1[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=1.Br[CH2:25][CH2:26][N:27]1[C:31](=[O:32])[C:30]2=[CH:33][CH:34]=[CH:35][CH:36]=[C:29]2[C:28]1=[O:37]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:9]([C:17]2[CH:18]=[CH:19][C:20]([Cl:23])=[CH:21][CH:22]=2)=[CH:10][C:11]([C:15]#[N:16])=[C:12]([O:14][CH2:25][CH2:26][N:27]2[C:28](=[O:37])[C:29]3[C:30](=[CH:33][CH:34]=[CH:35][CH:36]=3)[C:31]2=[O:32])[N:13]=1

Participants

3

Reactant 2

HCID 113251H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-HCID 219849076-(2-Chlorophenyl)-5-(4-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile

Product 1

HCID 58961583HCID 58961583, compound

Procedure

Using the procedure described in Example 25, 6-(2-chlorophenyl)-5-(4-chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile from Step C of Example 129 was reacted with N-(2-bromoethyl)phthalimide to afford the title compound. MS (electrospray) m/e 513.9 MH+ (Rt=4.2 min LC/MS).

Sources & evidence

ORD record
ord-014b89ecb30f4760b29fe9ab9fabea37
Source dataset
uspto-grants-2007_09
Patent number
US07271266B2

Reaction notes

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