HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 2-[(Ethylamino)Carbonyl]amino-1,3-benzothiazole-6-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | N-(6-Cyano-1,3-benzothiazol-2-yl)-N'-ethylurea | HCID 21985533 | — |
| Product | 2-[(Ethylamino)Carbonyl]amino-1,3-benzothiazole-6-carboxamide | HCID 85789296 | — |
Reaction Steps
About 1 g of N-(6-cyano-1,3-benzothiazol-2-yl)-N′-ethylurea was charged into about 30 mL of aqueous alkanol. Added about 0.6 g hydroxylamine hydrochloride and about 0.45 g sodium carbonate then heated to reflux. The solution was refluxed for about 4–8 hours then cooled to room temperature. The precipitate was recovered by filtration and washed well with water. LC/MS indicated a mixture of two products identified as the following after further purification by preparative HPLC:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07091227B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-42e183c75b274ca58d1e4a2d590f020c |
| Source note | uspto-grants-2006_08 |