Potassium Hydroxide → HCID 10270013, compound

Participants

Reaction Conditions

Reaction Steps

Potassium hydroxide (2 M, 0.9 ml) is added to a solution of 4-[8-(3-Methoxy-phenyl)-[1,7]naphthyridin-6-yl]-cyclohexanecarboxylic acid ethyl ester (230 mg, 0.6 mmol) in THF/ethanol (6 ml:2 ml) and heated at 80° C. for 3 hours. The solution is then diluted with ethyl acetate (120 ml) and extracted with water. The aqueous layer is taken to pH 4 with 1M HCl to give a white precipitate, which is extracted into dichloromethane (DCM). The DCM layer is washed with water, then dried over magnesium sulfate, filtered and concentrated to yield the desired product. M.p 209-212° C. MS (AP+) 362.9

Provenance & Evidence