Potassium Carbonate → HCID 66916474, compound

Participants

Reaction Steps

Potassium carbonate (10.1 mg, 0.074 mmol) in water (1 ml) is added to a solution of {4-[8-(3-cyano-phenyl)-[1,7]naphthyridin-6-yl]cyclohexyloxy}-acetic acid (59 mg, 0.15 mmol) in methanol (6 ml). The reaction mixture is stirred at room temperature for 30 minutes, filtered and concentrated. The product is lyophilised from water (×3) then dried at 40° C. in vacuo for 18 hours. Recrystallisation from CH2Cl2/ether gives the product. m.p 148-150° C. (decomp.) MS (ES+) [M+H]+ 388.1635

Provenance & Evidence