HCID 24738505, compound → HCID 69397306, compound

HRID 917319Notes

Reaction equation

HRID 917319 reaction equation
[CH2:1]([O:3][C:4]([CH:6]1[CH2:11][CH2:10][CH:9]([C:12]2[CH:13]=[C:14]3[C:19](=[C:20]([C:22]4[CH:27]=[CH:26][CH:25]=[C:24](C#N)[CH:23]=4)[N:21]=2)[N:18]=[CH:17][CH:16]=[CH:15]3)[CH2:8][CH2:7]1)=[O:5])[CH3:2].[F:30][C:31]([F:58])([F:57])[O:32]C1C=C(C2N=C(OS(C(F)(F)F)(=O)=O)C=C3C=2N=CC=C3)C=CC=1>>[CH2:1]([O:3][C:4]([CH:6]1[CH2:7][CH2:8][CH:9]([C:12]2[CH:13]=[C:14]3[C:19](=[C:20]([C:22]4[CH:27]=[CH:26][CH:25]=[C:24]([O:32][C:31]([F:58])([F:57])[F:30])[CH:23]=4)[N:21]=2)[N:18]=[CH:17][CH:16]=[CH:15]3)[CH2:10][CH2:11]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 24738505HCID 24738505, compoundHCID 71499996HCID 71499996, compound

Product 1

HCID 69397306HCID 69397306, compound

Procedure

This compound is prepared in an analogous way to compound 4-[8-(3-cyano-phenyl)-[1,7]naphthyridin-6-yl]-cyclohexanecarboxylic acid ethyl ester from trifluoromethanesulfonic acid 8-(3-trifluromethoxyphenyl)-[1,7]naphthyridin-6-yl ester. Purification is by chromatography followed by trituration with ether to yield a white solid. MS (AP+) 445

Workup

  1. customPurification
  2. customto yield a white solid

Sources & evidence

ORD record
ord-01ffcd07f5894203941ab63e585784bd
Source dataset
uspto-grants-2007_09
Patent number
US07273875B2

Reaction notes

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