HCID 17989739, compound → HCID 10200674, compound

Participants

Reaction Steps

A solution of 4-[8-(3-Methanesulfanyl-phenyl)-[1,7]naphthyridin-6-yl]-cyclohexanecarboxylic acid (30 mg, 0.079 mmol) in THF (1.4 ml) is cooled in a salt/ice bath and oxone (14.5 mg, 0.024 mmol) in water (0.5 ml) is added. After 15 minutes the reaction mixture is allowed to warm to room temperature and after a further 30 minutes more oxone (14.5 mg is added). The mixture is diluted with ethyl acetate/water and the aqueous layer extracted with ethyl acetate. The combined organic layers are washed with brine then dried over magnesium sulfate. Filtration followed by evaporation yields a foam consisting of title compound and 4-[8-(3-Methanesulfonyl-phenyl)-[1,7]naphthyridin-6-yl]-cyclohexanecarboxylic acid. MS (AP+) 395.87

Provenance & Evidence