Sodium Chloride → HCID 23032430, compound

Participants

Reaction Steps

Into 2 ml of N,N-dimethylformamide was dissolved 218 mg of 2-pyridylmethanol, 84 mg of sodium hydride (60% in oil) was added thereto under ice-cooling. After stirring for 15 minutes, a solution of 334 mg of 5-chloro-3-methylthio-1,2,4-thiadiazole in 2 ml of N,N-dimethylformamide was added dropwise into the mixture and the reaction mixture was stirred for 0.5 hour under ice-cooling and for 2 hours at room temperature. The reaction mixture was added to saturated sodium chloride aqueous solution, and extracted with t-butyl methyl ether. The organic layer was concentrated, and the residue obtained was subjected to silica gel column chromatography to give 30 mg of 5-(2-pyridylmethyloxy)-3-methylthio-1,2,4-thiadiazole (hereinafter, referred to as the present compound (19)).

Provenance & Evidence