3-Pyridinemethanol → HCID 23032463, compound

Participants

Reaction Steps

Into 2 ml of N,N-dimethylformamide were dissolved 100 mg of 5-chloro-3-methylthio-1,2,4-thiadiazole and 78 mg of 3-pyridinemethanol, 78 mg of sodium hydride (60% in oil) was added thereto under ice-cooling, and the reaction mixture was stirred for 0.5 hour under ice-cooling and for 1 hours at room temperature. The reaction mixture was added to saturated ammonium chloride aqueous solution, and extracted with t-butyl methyl ether. The organic layer was concentrated, and the residue obtained was subjected to silica gel column chromatography to give 88 mg of 5-(3-pyridylmethyl)-3-methylthio-1,2,4-thiadiazole (hereinafter, referred to as the present compound (20)).

Provenance & Evidence