Benzyl Alcohol → HCID 12151386, compound

Participants

Reaction Steps

Into 3 ml of N,N-dimethylformamide were dissolved 416 mg of 5-chloro-3-(4-chlorobenzylthio)-1,2,4-thiadiazole and 162 mg of benzyl alcohol, 48 mg of sodium hydride (60% in oil) was added thereto under ice-cooling, and the reaction mixture was stirred for 15 minutes under ice-cooling and for 1 hour at room temperature. The reaction mixture was added to saturated sodium chloride aqueous solution, and extracted with t-butyl methyl ether. The organic layer was concentrated, and the residue obtained was subjected to silica gel column chromatography to give 400 mg of 5-benzyloxy-3-(4-chlorobenzyl)thio-1,2,4-thiadiazole (hereinafter, referred to as the present compound (32)).

Provenance & Evidence