Acetic Anhydride → 5-Bezyloxy-3-acetoxymethythio-1,2,4-thiadiazole

Participants

Reaction Steps

Into 1.5 g of acetic anhydride were added 620 mg of 2,6-lutidine and 500 mg of 5-benzyloxy-3-methylsulfinyl-1,2,4-thiadiazole under ice-cooling. After stirring for 15 hours at room temperature, the reaction mixture was added to saturated sodium hydrogen carbonate aqueous solution, and extracted with t-butyl methyl ether. The organic layer was concentrated, and the residue obtained was subjected to silica gel column chromatography to give 376 mg of 5-bezyloxy-3-acetoxymethythio-1,2,4-thiadiazole (hereinafter, referred to as the present compound (44)).

Provenance & Evidence