HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → Diisopropylethylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Diisopropylethylamine | HCID 81531 | — |
Reaction Steps
The amine 8 may be coupled to a carboxylic acid using 1-ethyl-3-(3-dimethylainopropyl)carbodiimide (EDC), 1-hydroxybenztriazole (HOBT), and a base, generally triethylamine or diisopropylethylamine (DIPEA), in a solvent such as N,N-dimethylformamide (DMF), tetrahydrofuran (THF), or methylene chloride for 3 to 48 hours at ambient temperature to provide intermediate 10.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07273876B2 |
| Source dataset | uspto-grants-2007_09 |
| ORD ID | ord-af883398386d4ab4ace534c64f2c3a94 |
| Source note | uspto-grants-2007_09 |