Dimethylformamide → HCID 69181661, compound

Participants

Reaction Conditions

Reaction Steps

To 7 ml of N,N-dimethylformamide were dissolved 0.68 g (3.0 mmol) of 6,6-difluoro-5-methyl-5-hexenylmethanesulfonate and 0.58 g (3.6 mmol) of 1H-indole-5-carboxylic acid, followed by the addition of 0.75 g (8.9 mmol) of sodium hydrogencarbonate and stirring at 100° C. for 3 hours. The reaction liquid was then poured in water and extracted with diethyl ether. The organic layer was washed with water and a saturated saline solution in this order, followed by drying over anhydrous magnesium sulfate and concentration under reduced pressure. The residue was purified with silica gel column chromatography (ethyl acetate:hexane=1:3) to obtain 0.81 g (yield: 93%) of 6,6-difluoro-5-methyl-5-hexenyl 1H-indole-5-carboxylate.

Provenance & Evidence