反应详情

To 40 ml of ethanol, 10.0 g (39 mmol) of ethyl 2-benzyl-4-methylpyrimidine-5-carboxylate was dissolved, followed by adding 12.5 g (78 mmol) of 25% sodium hydroxide aqueous solution and stirring at room temperature for 15 hours. Ethanol was then removed, and the residue was dissolved in 100 ml of water, and 10% hydrochloric acid was added to make acidic. Crystal precipitated was filtered, washed with water and dried to obtain 8.10 g (yield: 91%) of 2-benzyl-4-methylpyrimidine-5-carboxylic acid.

1. customEthanol was then removed
2. dissolutionthe residue was dissolved in 100 ml of water
3. addition10% hydrochloric acid was added
4. customCrystal precipitated
5. filtrationwas filtered
6. washwashed with water
7. customdried