Sodium Hydroxide → HCID 23020286, compound

HRID 917385Notes

Reaction equation

HRID 917385 reaction equation
[CH2:1]([C:8]1[N:13]=[C:12]([CH3:14])[C:11]([C:15]([O:17]CC)=[O:16])=[CH:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>C(O)C>[CH2:1]([C:8]1[N:13]=[C:12]([CH3:14])[C:11]([C:15]([OH:17])=[O:16])=[CH:10][N:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 12194769Ethyl 2-benzyl-4-methylpyrimidine-5-carboxylate

Product 1

HCID 23020286HCID 23020286, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 40 ml of ethanol, 10.0 g (39 mmol) of ethyl 2-benzyl-4-methylpyrimidine-5-carboxylate was dissolved, followed by adding 12.5 g (78 mmol) of 25% sodium hydroxide aqueous solution and stirring at room temperature for 15 hours. Ethanol was then removed, and the residue was dissolved in 100 ml of water, and 10% hydrochloric acid was added to make acidic. Crystal precipitated was filtered, washed with water and dried to obtain 8.10 g (yield: 91%) of 2-benzyl-4-methylpyrimidine-5-carboxylic acid.

Workup

  1. customEthanol was then removed
  2. dissolutionthe residue was dissolved in 100 ml of water
  3. addition10% hydrochloric acid was added
  4. customCrystal precipitated
  5. filtrationwas filtered
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-6648a7f52b444d10a9522d8a139f9e7a
Source dataset
uspto-grants-2007_09
Patent number
US07273878B2

Reaction notes

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