Sodium Hydroxide → 472805-56-4

HRID 917387Notes

Reaction equation

HRID 917387 reaction equation
[CH:1]1([C:7]2[S:8][C:9]([C:13]([O:15]CC)=[O:14])=[C:10]([CH3:12])[N:11]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[Na+]>CO>[CH:1]1([C:7]2[S:8][C:9]([C:13]([OH:15])=[O:14])=[C:10]([CH3:12])[N:11]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 23020202HCID 23020202, compound

Product 1

HCID 23020345472805-56-4Yield 83.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 20 ml of methanol, 17.3 g (68 mmol) of ethyl 2-cyclohexyl-4-methylthiazole-5-carboxylate was dissolved, followed by adding 24 g (150 mmol) of 25% sodium hydroxide aqueous solution and stirring at room temperature for 15 hours. Methanol was removed, and the residue was then dissolved in 200 ml of water, and 10% hydrochloric acid was added to make acidic. Crystal precipitated was filtered, washed with water and dried to obtain 12.8 g (yield: 83%) of 2-cyclohexyl-4-methylthiazole-5-carboxylic acid.

Workup

  1. customMethanol was removed
  2. dissolutionthe residue was then dissolved in 200 ml of water
  3. addition10% hydrochloric acid was added
  4. customCrystal precipitated
  5. filtrationwas filtered
  6. washwashed with water
  7. customdried

Sources & evidence

ORD record
ord-5b4adfb15c0d444f8b2900bf9b1cd407
Source dataset
uspto-grants-2007_09
Patent number
US07273878B2

Reaction notes

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