反应详情

To 50 ml of acetone, 10.0 g (42 mmol) of ethyl 2-butoxy-4-methylpyrimidine-5-carboxylate was dissolved, followed by adding 50 ml of water, then adding drop-wise 13.4 g (84 mmol) of a 25% sodium hydroxide aqueous solution, and stirring at room temperature for 1 hour. The reaction liquid was concentrated at 40° C. under reduced pressure to remove acetone, and 10% hydrochloric acid was added to make acidic. The crystal precipitated was filtered, washed with water and dried to obtain 8.00 g (yield: 91%) of 2-butoxy-4-methylpyrimidine-5-carboxylic acid.

1. customThe reaction liquid
2. concentrationwas concentrated at 40° C. under reduced pressure
3. customto remove acetone, and 10% hydrochloric acid
4. additionwas added
5. customThe crystal precipitated
6. filtrationwas filtered
7. washwashed with water
8. customdried