Potassium Carbonate → (4-Thioureido-benzyl)-carbamic Acid Tert-butyl Ester

Participants

Reaction Steps

To a stirred near solution of tert-butyl N-(4-{[(benzoylamino)carbothioyl]amino}benzyl)-carbamate (10.4 g, 27.0 mmol) in MeOH (150 ml) was added a solution of K2CO3 (8.5 g, 61.5 mmol) in 15 ml water. The solution was stirred at room temperature for 24 hours and filtered to remove a white precipitate. The filtrate was evaporated in vacuo to yield 100% (7.6 g) of the desired product as an off-white solid.

Provenance & Evidence