HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-[4-(aminomethyl)cyclohexyl]-N-isopropylformamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | tert-butyl N-[4-(isopropylformylamino)cyclohexyl]methylcarbamate | HCID 22253966 | — |
| Product | N-[4-(aminomethyl)cyclohexyl]-N-isopropylformamide | HCID 15896073 | 100% |
Reaction Steps
Dioxane containing HCl (10 ml of 4N HCl solution) was added to a solution of tert-butyl N-[4-(isopropylformylamino)-cyclohexyl]methylcarbamate dissolved in 10 ml Et2O, stirred at room temperature for 2 hours, and the solvent removed to obtain N-[4-(aminomethyl)cyclohexyl]-N-isopropylformamide: 100% yield, 199 (ESMS, MH+); 1H NMR (CD3OD) δ 8.16 (s, 1H), 4.16 & 3.57 (two m, 1H), 3.70 (m, 1H), 2.79 (m, 2H), 1.36 (m, 6H), 1.91-1.06 (m, 9H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07273880B2 |
| Source dataset | uspto-grants-2007_09 |
| ORD ID | ord-d036fd6e1bab413a843a3455d0f9ca74 |
| Source note | uspto-grants-2007_09 |