Tetrahydrofuran → HCID 58963169, compound

Participants

Reaction Steps

A mixture of methyl 2-(4-cyanophenylamino)-2-(7-ethyl-3-methylbenzofuran-5-yl)acetate 5 (1.11 g, 3.18 mmol), LiOH.H2O (700 mg, 15.9 mmol), THF (10 mL) and water (5 ml) was stirred vigorously for 3 h. The mixture was partitioned between 1N HCl (100 ml) and ethyl acetate (100 ml). The aqueous layer was extracted with ethyl acetate (3×50 mL). The combined organic layers were washed with brine (1×125 mL), dried (MgSO4), filtered, and concentrated to yield 1.09 g (98%) of 2-(4-cyanophenylamino)-2-(7-ethyl-3-methylbenzofuran-5-yl)acetic acid 6 as an off-white solid.

Provenance & Evidence