Sodium Hydroxide → HCID 58962952, compound

Participants

Reaction Steps

The solution of 3.50 g of 1,3-bis(azidomethyl)-5-chlorobenzene in THF (20 mL) was added slowly to the LAH (1.33 g, 35.0 mmol) suspension in THF at 0° C. The resulting reaction mixture was stirred at RT for 1 hr. and then at reflux for another hour. Slow addition of 2 mL of 5% NaOH solution resulted a precipitate, which was removed by filtration. The product on solid was rinsed off with THF. The solvent was evaporated in vacuo to yield 2.60 g of 3-(aminomethyl)-5-chlorobenzylamine. 1H NMR (500 MHz, CD3OD) δ 7.25 (s, 2 H), 7.21 (s, 1 H), 3.76 (s, 4 H).

Provenance & Evidence