反应详情

Step N1. A mixture of dimethyl 5-chloroisophthalate (6.84 g, 30 mmol), in methanol (150 mL) was treated with 1M sodium hydroxide (27 mL, 27 mmol) and the reaction stirred at room temperature for 16 hours. The mixture was concentrated under vacuum and the resulting residue was dissolved in water. The mixture was extracted with ethyl acetate three times. The organic extract was dried over anhydrous sodium sulfate, filtered and concentrated to afford 3-chloro-5-(methoxycarbonyl)benzoic acid (4.8 g, 75%).

1. concentrationThe mixture was concentrated under vacuum
2. dissolutionthe resulting residue was dissolved in water
3. extractionThe mixture was extracted with ethyl acetate three times
4. extractionThe organic extract
5. dry with materialwas dried over anhydrous sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated