Potassium Iodide → HCID 178489173, compound

Participants

Reaction Steps

The compound of Example 23 (8.3 mg, 0.020 mmol), 1-bromo-2-chloroethane (14 mg, 0.1 mmol), cesium carbonate (13 mg, 0.04 mmol) and potassium iodide (4 mg, 0.024 mmol) were mixed in 1 mL of THF in an 8-mL glass vial. The vial was capped and shaken at RT overnight. The reaction mixture was filtered through Acrodisc Syringe Filter (0.45 μm). Solvent was evaporated in vacuo. The residue was purified by preparative HPLC to give 2.2 mg of the title compound. LC/MS (method A) RT 2.61, MH+ 477. 1H NMR (500 MHz, CD3OD) δ 7.60 (d, J=8.2 Hz, 2H), 7.05 (d, J=8.2 Hz, 2H), 6.99 (s, 2H), 6.90 (s, 1 H), 4.53 (s, 2 H), 4.26 (t, J=5.3 Hz, 2 H), 3.86 (t, J=5.3 Hz, 2 H), 3.84 (s, 3 H), 2.66 (s, 3 H).

Provenance & Evidence