Sodium Hydroxide → HCID 12042526, compound

HRID 917571Notes

Reaction equation

HRID 917571 reaction equation
[OH-].[Na+].[C:3]([C:5]1[CH:6]=[C:7]([NH:11][CH:12]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:13]([O:15]C)=[O:14])[CH:8]=[CH:9][CH:10]=1)#[N:4]>CO>[C:3]([C:5]1[CH:6]=[C:7]([NH:11][CH:12]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:13]([OH:15])=[O:14])[CH:8]=[CH:9][CH:10]=1)#[N:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 12042525HCID 12042525, compound

Product 1

HCID 12042526HCID 12042526, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

50 ml of 1 N sodium hydroxide solution are added to a solution of 9.5 g (35.6 mmol) of methyl (3-cyanophenylamino)-2-phenylacetate in 150 ml of methanol, and the mixture is stirred at room temperature for 21 hours. The reaction mixture is evaporated, the residue is acidified to pH 1 using 25% HCl, and the resultant precipitate is filtered off, giving (3-cyanophenylamino)-2-phenylacetic acid as colourless crystals of m.p. 159-162°.

Workup

  1. customThe reaction mixture is evaporated
  2. filtrationthe resultant precipitate is filtered off

Sources & evidence

ORD record
ord-c476ca3c44d246eebf718c381c704de1
Source dataset
uspto-grants-2007_09
Patent number
US07273867B2

Reaction notes

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