Acetic Acid → 3,5-Dioxohexanoic acid

Participants

Reaction Steps

500 mg of water-moist Raney nickel and 0.1 ml of acetic acid are added to a solution of 150 mg (0.337 mmol) of 2-[3-(N-hydroxyamidino)phenylamino]-N-(4-morpholin-4-ylphenyl)-2-phenylacetamide in 5 ml of methanol, and the mixture is hydrogenated at room temperature and atmospheric pressure for 18 hours. The reaction mixture is filtered, and the residue is evaporated, giving 2-(3-amidinophenylamino)-N-(4-morpholin-4-ylphenyl)-2-phenylacetamide, triacetate, ESI 430; IC50 (Xa)=3.4×10−8 M; IC50 (VIIa)=2.2×10−8 M;

Provenance & Evidence