HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 917591Generated: October 31, 2026
2-Pyridinemethanamine → HCID 17848351, compound
https://huagongshe.com/reaction/917591
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Pyridinemethanamine | HCID 19509 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | HCID 22619321 | HCID 22619321 | — |
| Reactant | 4-((3-Chloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylic acid | HCID 22665572 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 17848351 | HCID 17848351 | — |
Reaction Steps
2-Methylthio-4-(3-chloro-4-methoxybenzylamino)-5-carboxypyrimidine (prepared in Example 79) 0.500 g, 2-pyridylmethylamine 0.1749 g, 1-hydroxybenzotriazole 0.1987 g, 1,2-dichloroethane hydrochloride 0.3102 g and anhydrous dimethylformamide 5 ml are mixed together and stirred at 0° C. overnight and triturated with ethyl acetate-isopropyl ether to give 2-methylthio-4-(3-chloro-4-methoxybenzylamino)-5-[N-(2-pyridylmethyl)carbamoyl]pyrimidine as a colorless powder, 0.5966 g. mp 143-144.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07273868B2 |
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| Source dataset | uspto-grants-2007_09 |
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| ORD ID | ord-527289b4f7ca46aa9389884d8cbb2f37 |
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| Source note | uspto-grants-2007_09 |
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