Dichloromethane → HCID 21985551, compound

Participants

Reaction Steps

About 0.2 g of 2-[(ethylamino)Carbonyl]amino-1,3-benzothiazole-6-carboxylic acid was dissolved into about 20 mL dichloromethane and about 0.2 mL triethylamine. Added about 1 eq of the appropriate amine followed by about 0.3 g of 1-ethyl-3-(3-dimethylaminopropyl)Carbodiimide hydrochloride then stirred at room temperature for about 12–24 hours. The solvent was removed under reduced pressure then the crude reaction mixture was purified by preparative HPLC. 1H NMR 1.10 (t, 3H), 3.2 (m, 2H), 6.76 (br s, 11), 7.10 (m, 1H), 7.36 (m, 2H), 7.70 (d, 1H), 7.79 (d, 2H), 7.97 (m, 1H), 8.5 (s, 1H), 10.23 (s, 1H), 10.9 (br s, 1H); LC/MS 2.86 min, 341 (M+1);

Provenance & Evidence