HCID 21100058, compound → HCID 17848310, compound

HRID 917600Notes

Reaction equation

HRID 917600 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[C:12]([Cl:18])[CH:11]=2)[C:5]([CH:19]([OH:26])[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=2)=[CH:4][N:3]=1>[O-2].[O-2].[Mn+4].C(Cl)(Cl)Cl>[Cl:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[C:12]([Cl:18])[CH:11]=2)[C:5]([C:19]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=2)=[O:26])=[CH:4][N:3]=1

Participants

4

Reactant 1

HCID 21100058HCID 21100058, compound

Product 1

HCID 17848310HCID 17848310, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6212ChloroformSolvent

Procedure

A mixture of 2-chloro-4-(3-chloro-4-methoxybenzylamino)-5-[(hydroxy)(2-pyridyl)methyl]pyrimidine (prepared in the above (2)) 46 mg, manganese dioxide 230 mg and chloroform 2.3 ml is stirred at room temperature for 3 hours. After removal of insoluble substances by filtration, the filtrate is concentrated in vacuo to give 2-chloro-4-(3-chloro-4-methoxybenzylamino)-5-(2-pyridylcarbonyl)pyrimidine 39 mg. mp 117-119° C. (recrystalization from diethyl ether), MS(m/z): 389(M+H)+

Workup

  1. customAfter removal of insoluble substances
  2. filtrationby filtration
  3. concentrationthe filtrate is concentrated in vacuo

Sources & evidence

ORD record
ord-6e09e0a89faf4b1c9853309195827c31
Source dataset
uspto-grants-2007_09
Patent number
US07273868B2

Reaction notes

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