Propargyl alcohol → HCID 11255499, compound

Participants

Reaction Steps

4-(2-Fluoro-4-iodoanilino)-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide was reacted with propargyl alcohol in the presence of CuI, (Ph3P)2PdCl2 and TEA in DMF as for example 2. The residue resulting from removal of the reaction solvents under reduced pressure was purified by column chromatography on silica gel (5% MeOH/CH2Cl2 as eluant) to give 4-[2-fluoro-4-(3-hydroxy-1-propynyl)anilino]-1-methyl-6-oxo-1,6-dihydro-3-pyridinecarboxamide as an off-white solid (89%). 1H NMR [(CD3)2SO, 400 MHz] δ 10.57 (s, 1 H), 8.35 (s, 1H), 7.90 (br s, 1H), 7.50 (t, J=8.5 Hz, 1H), 7.48 (br s, 1H), 7.39 (dd, J=11.4, 1.8 Hz, 1H), 7.28 (dd, J=8.3, 1.5 Hz, 1H), 5.69 (s, 1H), 5.36 (t, J=6.0 Hz, 1H), 4.30 (d, J=5.9 Hz, 2H), 3.37 (s, 3H). LCMS (APCI+) calcd for C16H15FN3O3 316 (MH+), found 316.

Provenance & Evidence