Sodium Hydroxide → HCID 58962839, compound

Participants

Reaction Steps

Ethyl 4-(2-fluoro-4-iodoanilino)-1-[2-(2-methoxyethoxy)ethyl]-6-oxo-1,6-dihydro-3-pyridinecarboxylate was dissolved in EtOH and treated with 1 M NaOH, as for example 1, step C, to hydrolyse the ester to give 4-(2-fluoro-4-iodoanilino)-1-[2-(2-methoxyethoxy)ethyl]-6-oxo-1,6-dihydro-3-pyridinecarboxylic acid as a cream solid (99%), used directly in the next step. 1H NMR [(CD3)2SO, 400 MHz] δ 13.00 (v br s, 1H), 9.72 (br s, 1H), 8.41 (s, 1H), 7.75 (dd, J=10.1, 1.9 Hz, 1H), 7.60 (ddd, J=8.3, 1.9, 0.8 Hz, 1H), 7.32 (t, J=8.5 Hz, 1H), 5.47 (d, 1.2 Hz, 1H), 4.05 (t, J=5.2 Hz, 2H), 3.60 (t, J=5.2 Hz, 2H), 3.53-3.50 (m, 2H), 3.42-3.38 (m, 2H), 3.21 (s, 3H). HRMS (EI+) calcd C17H18FIN2O5 (M+) 476.0245, found 476.0236.

Provenance & Evidence