反应详情

4-Bromo-2-fluoroaniline and ethyl 4,6-dichloronicotinate were reacted in a mixture of EtOH and conc. HCl as for example 33, step A. The resultant solid was isolated by filtration and washed with 10% Et2O/Hexane, to give ethyl 4-(4-bromo-2-fluoroanilino)-6-chloronicotinate (58%); m.p. (EtOH/water) 150-152° C. 1H NMR [400 MHz, CDCl3] δ 9.74 (br s, 1H), 8.81 (s, 1H), 7.41 (dd, J=9.6, 2.2 Hz, 1H), 7.38-7.35 (m, 1H), 7.25 (t, J=8.3 Hz, 1H), 6.71 (d, J=1.5 Hz, 1H), 4.42 (q, J=7.1 Hz, 2H), 1.43 (t, J=7.1 Hz, 3H). MS (FAB+) 375 (16%).

1. customThe resultant solid was isolated by filtration
2. washwashed with 10% Et2O/Hexane