HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4,6-dichloropyridine-3-carboxylate → HCID 58962865, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4,6-dichloropyridine-3-carboxylate | HCID 600045 | — |
| Reactant | 4-Ethyl-2-fluoroaniline | HCID 21161339 | — |
| Catalyst | Hydrochloric Acid | HCID 313 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 58962865 | HCID 58962865 | 100% |
Reaction Steps
Ethyl 4,6-dichloronicotinate (31.62 g, 144.0 mmol) and 4-Ethyl-2-fluoro-phenylamine (20.0 g, 144.0 mmol) were dissolved in EtOH (200 mL), to which was added conc. HCl (6 drops) as for Example 1, alternate Step A to give 6-Chloro-4-(4-ethyl-2-fluoro-phenylamino)-nicotinic acid ethyl ester (46.50 g, 99%). (APCI+) calcd for C16H18ClFIN2O2 322.76 (M−1), found 321.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07273877B2 |
| Source dataset | uspto-grants-2007_09 |
| ORD ID | ord-b0a07d902488479685d871a509cecae4 |
| Source note | uspto-grants-2007_09 |