HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-acetyl-1H-indole-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | HCID 4162576 | HCID 4162576 | — |
| Reactant | HCID 11770291 | HCID 11770291 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-acetyl-1H-indole-2-carboxylic acid | HCID 13705809 | — |
| Product | 3-Acetyl-1H-indole-2-carboxylic acid | HCID 15090443 | — |
Reaction Steps
Saponification of 2b and 3b with 10% KOH in ethanol at 60° C. for 1 h followed by acidification with 1M HCl provided 3-acetyl-1H-indole-2-carboxylic acid 4b and 5-acetyl-1H-indole-2-carboxylic acid 5b in 95% and 93% yield respectively. The crude acids were used directly without purification in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07273885B2 |
| Source dataset | uspto-grants-2007_09 |
| ORD ID | ord-8cbfd45909e14def8baf0760a41600b7 |
| Source note | uspto-grants-2007_09 |