HCID 68493961, compound → HCID 68491493, compound

Participants

Reaction Steps

Ester 13b (4.0 g, 8.4 mmol) was stirred in EtOH (40 mL) charged with 400 mg 10%Pd(OH)2/C. H2 gas was bubbled into the suspension until the reaction was complete. Catalyst was removed by filtration and the filtrate concentrated in vacuo to give 1-(2-amino-3,3-dimethyl-butyryl)-octahydro-indole-2-carboxylic acid tert-butyl ester 14b (2.8 g, 8.4 mmol, 100%) which was used as is in the next step without further purification.

Provenance & Evidence