Ammonia → HCID 21821194, compound

Participants

Reaction Steps

4-Cyano-1-(2,3,5-tri-O-acetyl-β -D-ribofuranosyl-1,2,3-triazole (8). (0.35 g, 0.001 mol) was added to 15% aqueous ammonia (30 ml) and 30% hydrogen peroxide (3 ml). The solution was stirred 4 hr before additional hydrogen peroxide was added. The procedure and product isolation was identical to that used in method 2 for compound 4. The compound was dissolved in hot 2-propanol; cooling of the solution and filtering provided 30 mg of crystalline 5 which was identical to an authentic sample prepared by the procedure of Alonso, et al. J. Heterocyclic Chem. 7, 1269 (1970).

Provenance & Evidence